The PI3K-AKT Pathway and Its Role in Tumorigenesis

The phosphoinositide 3-kinase/protein kinase B (PI3K-AKT) pathway is involved in the control of numerous critical cellular processes, including apoptosis, cell proliferation, and the cell cycle. It can be activated by many different growth factors, hormones, cytokines, and nutrients. PI3K-AKT pathway dysfunction has been observed in several diseases, including cancer, cardiovascular disease, and autoimmune and neurological disorders. In this animation, learn more about the molecular characteristics and function of the PI3K-AKT pathway and how AKT mutation plays a role in tumorigenesis.