Chromatography Videos

Follow the story of Evitria as it grows from a small Chinese hamster ovary (CHO) cell supernatant supplier to a global therapeutic antibody production company serving clients across the globe. Bio-Rad has partnered with Evitria at every stage of this remarkable journey and looks forward to supporting its continued success.

Large molecule purification presents significant challenges due to their considerable size. For instance, Immunoglobulin M (IgM) molecules, ranging from 900 to 1,000 kD, play pivotal roles in mammalian immune responses and find extensive applications in diagnostics and therapeutics. Purification of such molecules is particularly intricate owing to several factors including their weak Protein A binding sites, limited dynamic binding capacity, and slow diffusion rates.